|Year : 2020 | Volume
| Issue : 1 | Page : 1-2
Colistin resistance and rapid spread colistin resistance gene: A significant public health challenge worldwide
Shaheda Anwar Shampa1, Mainul Haque2
1 Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
2 Unit of Pharmacology, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia
|Date of Submission||24-Aug-2019|
|Date of Acceptance||09-Dec-2019|
|Date of Web Publication||03-Jan-2020|
Unit of Pharmacology, Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Perdana Sungai Besi, 57000 Kuala Lumpur
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Shampa SA, Haque M. Colistin resistance and rapid spread colistin resistance gene: A significant public health challenge worldwide. Adv Hum Biol 2020;10:1-2
|How to cite this URL:|
Shampa SA, Haque M. Colistin resistance and rapid spread colistin resistance gene: A significant public health challenge worldwide. Adv Hum Biol [serial online] 2020 [cited 2021 Dec 7];10:1-2. Available from: https://www.aihbonline.com/text.asp?2020/10/1/1/275088
Colistin, a peptide antibiotic, initially isolated in 1947 from a soil bacterium Paenibacillus polymyxa subsp., with substantial activity against Gram-negative microorganisms. The uses of colistin were restricted worldwide by the 1970s due to its toxic potential. Nevertheless, colistin is being considered as the last resort antibiotic for the infections caused by multidrug-resistant Gram-negative bacteria, including carbapenem-resistant Acinetobacter, Pseudomonas and carbapenem-resistant Enterobacteriaceae, the previous two decades. Colistin is widely used in livestock for infective disorders. The overall prevalence rate of resistance was low. However, there has been a remarkable increase in colistin-resistant strains in recent years. Plasmid-mediated colistin resistance gene mcr1 was first reported in China in 2015. All earlier reported resistance was chromosomally mediated. Multiple studies revealed that mcr1 gene rapidly spread among animals, travellers, trading food animals and human environment across the globe.,, Subsequently, plasmid-mediated resistance genes mcr2–mcr8 have been identified in various infections from humans and animals. The resistant genes have been detected in several Enterobacteriaceae species – Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Shigella sonnei, Enterobacter spp., Citrobacter spp., Providencia rettgeri, etc., from environment, food, humans, livestock, companion animals, vegetables, etc. Resistant colistin genes isolates were transmitted from animals to human. The coexistence of mcr1 with other resistance genes indicates the horizontal transmission and high potential of spread. One health concept recognises that human health is connected to animal health and the environment. Thereafter, the data regarding the colistin resistance of both animals and humans should be integrally analysed to monitor the distribution of the resistance pattern. Improving the biosafety, biosecurity and the diet of livestock significantly reduces the misuse of colistin. The last effective antimicrobial should only be utilised cautiously for absolute clinical necessity. The prudent use of colistin should be prompted. In addition, regulatory control measures need to implement both national and international level to minimise the overall consumption of antimicrobials and to safeguard the ultimate choice.
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