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CASE REPORT
Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 29-33

Hyperoeosinophilia at diagnosis in adolescent acute lymphoblastic leukaemia/lymphoma: A case report and review of the literature


1 Department of Clinical Hematology and Bone Marrow Transplant, Tata Medical Center, Kolkata, India
2 Faculty of Medicine and Defence Health, Universiti Pertahanan National Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, Kuala Lumpur, Malaysia

Correspondence Address:
Mainul Haque
Faculty of Medicine and Defence Health, Universiti Pertahanan National Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, 57000 Kuala Lumpur
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AIHB.AIHB_102_19

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Acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LBL) presenting as peripheral blood hyperoeosinophilia is a sporadic disorder with fewer than fifty cases described since 1973, and the cumulative incidence is <1%. ALL/LBL with hyperoeosinophilia and the absence of blasts in peripheral blood might lead to misdiagnosis of ALL/LBL. The physician should keep in mind that oeosinophilia can be part of acute leukaemia and should be carefully investigated. In this case report, we discuss a case of B cell ALL/LBL (B-ALL/B-LBL) with peripheral blood hyperoeosinophilia and in the absence of blasts in peripheral blood. A 17-year-old young boy presented with low-grade fever, itching, bilateral progressive limb weakness and pleural effusion. His bone marrow and paravertebral mass were diagnostic of B-ALL/B-LBL. Around half of the patients with ALL associated with hyperoeosinophilia show cytogenetic abnormalities and most common anomalies are t (5;14) (q31; q32), which is otherwise rare in ALL, but in the current case report, has normal karyotype.


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