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REVIEW ARTICLE
Year : 2023  |  Volume : 13  |  Issue : 1  |  Page : 10-16

An evidence-based review on host modulatory agents in treatment of peri-implant disease


Department of Periodontology, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Deemed to be University, Vadodara, Gujarat, India

Correspondence Address:
Dr. Jasuma Rai
Department of Periodontology, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Deemed to be University, Piparia, Waghodia, Vadodara - 391 760, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aihb.aihb_153_21

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Antimicrobials have traditionally been the only chemotherapeutic option for treating periodontitis and peri-implant disorders. With a growing understanding of the host–pathogen interactions in periodontal pathogenesis, novel therapeutic options for periodontitis and peri-implant disorders are developed by focusing on the host response with host-modulating drugs. When employed as host-modifying agents, a variety of sub-antimicrobial dose doxycycline (SDD), bisphosphonates and non-steroidal anti-inflammatory drugs were found to be successful in both experimental animal research and human trials. The current state and future prospects of host modulatory agents used to treat peri-implant disease are discussed in this evidence-based review.


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