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An evidence-based review on host modulatory agents in treatment of peri-implant disease
Mudra Andharia, Jasuma Rai, Monali Shah, Priyanka Sonavane
Department of Periodontology, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Deemed to be University, Vadodara, Gujarat, India
Correspondence Address:
Jasuma Rai,
Department of Periodontology, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Deemed to be University, Piparia, Waghodia, Vadodara - 391 760, Gujarat
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/aihb.aihb_153_21
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Antimicrobials have traditionally been the only chemotherapeutic option for treating periodontitis and peri-implant disorders. With a growing understanding of the host–pathogen interactions in periodontal pathogenesis, novel therapeutic options for periodontitis and peri-implant disorders are developed by focusing on the host response with host-modulating drugs. When employed as host-modifying agents, a variety of sub-antimicrobial dose doxycycline (SDD), bisphosphonates and non-steroidal anti-inflammatory drugs were found to be successful in both experimental animal research and human trials. The current state and future prospects of host modulatory agents used to treat peri-implant disease are discussed in this evidence-based review.
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