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  Indian J Med Microbiol
 

Figure 1: The role of SARS-CoV-2 viroporins in NLRP3 inflammasomes activation. The TRAF3-binding motif of the ORF3a can activate the NLRP3 inflammasome and promote the pro–IL1 β production. The ORF8b protein activates the NLRP3 inflammasome by interacting with the NLRP3. The E protein is another viroporin that promotes NLRP3 inflammasome activation and results in IL-1 β overproduction. Abbreviation: ACE2: Angiotensin-converting enzyme 2; PP: polyprotein; DMV: double-membrane vesicle; ERGIC: Endoplasmic Reticulum-Golgi Intermediate Compartment; ASC: Apoptosis-associated speck-like protein containing a caspase-recruitment domain; TRAF3: Tumour necrosis factor receptor-associated factor 3; ER: Endoplasmic Reticulum.

Figure 1: The role of SARS-CoV-2 viroporins in NLRP3 inflammasomes activation. The TRAF3-binding motif of the ORF3a can activate the NLRP3 inflammasome and promote the pro–IL1 β production. The ORF8b protein activates the NLRP3 inflammasome by interacting with the NLRP3. The E protein is another viroporin that promotes NLRP3 inflammasome activation and results in IL-1 β overproduction. Abbreviation: ACE2: Angiotensin-converting enzyme 2; PP: polyprotein; DMV: double-membrane vesicle; ERGIC: Endoplasmic Reticulum-Golgi Intermediate Compartment; ASC: Apoptosis-associated speck-like protein containing a caspase-recruitment domain; TRAF3: Tumour necrosis factor receptor-associated factor 3; ER: Endoplasmic Reticulum.